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Trends Microbiol. 1994 Oct;2(10):372-80.

Molecular structures of penicillin-binding proteins and beta-lactamases.

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Centre d'Ingénierie des Protéines, Université de Liège, Belgium.


In the past, new antibacterial agents have been selected either from natural sources or by 'trial and error' modification of existing antibacterials. Future therapeutic strategies are likely to depend on increased knowledge of existing drug targets and the search for new targets. The machinery for the assembly of bacterial-cell-wall peptidoglycan is an ideal place to look.

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