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Trends Microbiol. 1994 Oct;2(10):357-60.

Extrachromosomal resistance in gram-negative organisms: the evolution of beta-lactamase.

Author information

1
Lahey Clinic, Burlington, MA 01805.

Abstract

beta-Lactamases are the major defense used by bacteria to overcome the effects of penicillins, cephalosporins and related beta-lactam antibiotics. In the antibiotic era, the enzymes have evolved to become more prevalent, to appear in new hosts, to be expressed at higher levels, to be acquired by plasmids and to change catalytic properties to increase affinity for what were meant to be nonhydrolysable substrates or to reduce affinity for beta-lactamase inhibitors.

PMID:
7850201
DOI:
10.1016/0966-842x(94)90611-4
[Indexed for MEDLINE]

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