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Trends Microbiol. 1994 Oct;2(10):343-7.

Origin and evolution of DNA associated with resistance to methicillin in staphylococci.

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Dept of Medicine, Virginia Commonwealth University, Medical College of Virginia, Richmond 23298-0049.


The gene mediating resistance to methicillin in staphylococci (mecA) and its flanking sequences (mec DNA) make up a chromosomal DNA locus that is unique to methicillin-resistant bacteria; no equivalent locus exists in methicillin-susceptible cells. The origin of mec DNA is not known, but evidence supports horizontal transfer of mec DNA between different staphylococcal species and of the mecA gene between different Gram-positive genera.

[Indexed for MEDLINE]

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