Send to

Choose Destination
Crit Rev Oncog. 1994;5(2-3):297-311.

The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations.

Author information

Cell and Molecular Biology Department, University of California, Berkeley 94720.


From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-beta, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center