Format

Send to

Choose Destination
Pharmacol Ther. 1994 Oct;64(1):155-74.

Vascular targeting--a new approach to the therapy of solid tumors.

Author information

1
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235-8576.

Abstract

An attractive approach to the therapy of solid tumors is to attack the endothelial cells of the tumor vascular bed rather than the tumor cells themselves, which circumvents the problem of poor penetration of tumor masses by monoclonal antibodies and other macromolecules. In this review, we will discuss the drawbacks of targeting solid tumors and the advantages of the 'vascular targeting' approach, describe the validation of the concept in a mouse model and summarize the properties of tumor endothelial cell markers, which are candidates for vascular targeting in humans.

PMID:
7846113
DOI:
10.1016/0163-7258(94)90037-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center