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Med J Aust. 1995 Jan 2;162(1):15-8.

Depression of plasma glutamine concentration after exercise stress and its possible influence on the immune system.

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Department of Microbiology, University of Western Australia, Perth.



To determine whether plasma glutamine levels can be used as an indicator of exercise-induced stress, and to consider the possible effects of low plasma glutamine concentrations on the immune system.


We used two exercise regimens: in Trial 1 seven male subjects were randomly stressed on a treadmill at 0, 30%, 60%, 90% and 120% of their maximal oxygen uptake (VO2max); in Trial 2 five highly trained male subjects underwent intensive interval training sessions twice daily for ten days, followed by a six-day recovery period.


Plasma glutamine concentrations decreased significantly from an average of 1244 +/- 121 mumol/L to 702 +/- 101 mumol/L after acute exercise at 90% VO2max (P < 0.05) and to 560 +/- 79 mumol/L at 120% VO2max (P < 0.001). Four of the five subjects showed reduced plasma glutamine concentrations by Day 6 of the overload training trial, with all subjects displaying significantly lower glutamine levels by Day 11. However, glutamine levels showed a variable rate of recovery over the six-day recovery period, with two subjects' levels remaining low by Day 16.


Reduced plasma glutamine concentrations may provide a good indication of severe exercise stress.

[Indexed for MEDLINE]

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