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Int J Gynaecol Obstet. 1994 Nov;47(2):115-20.

Prevention of preeclampsia with calcium supplementation and vitamin D3 in an antenatal protocol.

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1
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan.

Abstract

OBJECTIVES:

Using an angiotensin sensitivity test we carried out a prospective study in an attempt to predict the possible onset of preeclampsia and to prevent it by calcium supplementation (elemental calcium 156 or 312 mg/day per os) and treatment with vitamin D3 (0.5 micrograms/3 day per os).

METHOD:

We used a study design in which 666 singleton pregnant women were managed with conventional antenatal care and 210 singleton pregnant women were managed with a protocol, together with conventional antenatal care.

RESULT:

Of the 666 women managed conventionally, 113 (16.9%) developed preeclampsia. However, the incidence of preeclampsia in the 210 women managed on the protocol was lower, at 10.9%.

CONCLUSION:

Our findings indicate that this protocol for the prediction and prevention of preeclampsia is useful for pregnant women at high risk of developing preeclampsia.

PMID:
7843479
[Indexed for MEDLINE]
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