Format

Send to

Choose Destination
FEBS Lett. 1995 Jan 30;358(3):225-9.

Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene.

Author information

1
Institute for Molecular and Cellular Biology, Osaka University, Japan.

Abstract

Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation.

PMID:
7843405
DOI:
10.1016/0014-5793(94)01426-2
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center