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J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):455-66.

The frontal lobes and content-specific delusions.

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  • 1Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island.


Contemporary research has shown that delusions are often the product of identifiable neurologic disease, particularly when the delusions have a specific theme or are confined to one topic--monosymptomatic or content-specific delusions. Although these delusions are considered rare, some of them can be found at high rates in certain populations and settings. The literature on several classes of content-specific delusions (misidentification, sexual, and somatic) is critically reviewed. The review demonstrates that when adequate diagnostic workups are conducted, a high proportion of such delusions are found to have a neurologic basis. Lesions of the frontal lobes and the right hemisphere are shown to be critical to the development and persistence of many content-specific delusions.

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