A model of instrumental conditioning similar to the classical model (Pavlovian) is proposed. Flexion of the ipsilateral forelimb was elicited while EDS was applied to the hind limb by stimulation of the motor area of the cortex (M1); both stimuli ceased during the raising of the forelimb. Uniform combinations of this kind led to the development of forepaw flexion reactions in response to the EDS of the hind paw. Prolongation of EDS by 3 sec following cortical stimulation led to rapid extinction of the developed reactions. Thus, the possibility of the effective instrumentalization of movements induced by stimulation of the M1 is proven. This argues that the forming "instrumental" connection (drive-motor structures) is addressed directly to the M1.