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Neurobiol Aging. 1994 Mar-Apr;15(2):207-13.

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats.

Author information

1
Department of Psychology, Johns Hopkins University, Baltimore, MD 21218.

Abstract

D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.

PMID:
7838293
DOI:
10.1016/0197-4580(94)90114-7
[Indexed for MEDLINE]

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