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Immunology. 1994 Aug;82(4):645-50.

Characterization of liver lymphomyeloid cells in mice infected with Plasmodium yoelii sporozoites.

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Institut National de la Santé et de la Recherche Médicale, Département de Parasitologie, Groupe Pitié-Salpêtrière, Paris, France.


We have isolated, characterized and quantified the immunocompetent cells present in the extravascular hepatic compartment at various stages after Plasmodium yoelii malaria infection with sporozoites. Cytological analyses revealed a predominantly lymphoid population. In mice with a primary infection, the predominant cells were CD4+, CD8+ and B lymphocytes. In fully protected mice, CD3+ CD4- CD8- and polymorphonuclear cells, particularly eosinophils, were most common. The significance of changes in subpopulations is discussed in relation to antigen presentation and host-protective mechanisms.

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