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Curr Opin Cell Biol. 1994 Oct;6(5):752-8.

Microbial adhesins recognizing extracellular matrix macromolecules.

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Institute of Biosciences and Technology, Texas A & M University, Houston 77030.


Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.

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