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Curr Opin Cell Biol. 1994 Oct;6(5):711-6.

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.

Author information

1
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

Abstract

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.

PMID:
7833051
DOI:
10.1016/0955-0674(94)90098-1
[Indexed for MEDLINE]

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