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Curr Opin Cell Biol. 1994 Oct;6(5):705-10.

Focal adhesion kinase and associated proteins.

Author information

1
Department of Microbiology, University of Virginia, Charlottesville 22908.

Abstract

Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine kinases, and the focal adhesion associated protein paxillin. Through these interactions, pp125FAK may regulate signalling via different extracellular ligands.

PMID:
7833050
DOI:
10.1016/0955-0674(94)90097-3
[Indexed for MEDLINE]

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