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Biochem Biophys Res Commun. 1995 Jan 26;206(3):895-901.

Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro.

Author information

1
Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland.

Abstract

The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2- and 16 alpha-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.

PMID:
7832802
DOI:
10.1006/bbrc.1995.1127
[Indexed for MEDLINE]

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