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J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):228-32.

The minigrafting test for vitiligo: detection of stable lesions for melanocyte transplantation.

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1
Department of Internal Medicine, Fundacion Valle del Lili, Cali, Columbia.

Abstract

BACKGROUND:

Selected patients with stable and refractory vitiligo may consider melanocyte transplantation as a therapeutic alternative. A method to anticipate the response to surgical repair is not available.

OBJECTIVE:

We evaluated the pigment spread of minigrafts when implanted within achromic lesions of stable vitiligo as a test to identify good candidates for surgical repigmentation.

METHODS:

Four to six minigrafts of 1.0 to 1.2 mm were implanted within lesions of patients with unilateral (localized) and bilateral (generalized) vitiligo. Pigment spread was assessed 3 months later.

RESULTS:

Forty-seven subjects were examined. In unilateral vitiligo 19 of 20 patients (95%) had a positive test result in comparison with only 13 of 27 patients (48%) with bilateral vitiligo (p = 0.002).

CONCLUSION:

The minigrafting test is a reliable tool to identify patients with stable vitiligo who may respond to melanocyte transplantation. Unilateral (localized) vitiligo is the best indication for surgical repigmentation.

PMID:
7829707
[Indexed for MEDLINE]

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