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Dev Biol Stand. 1976;33:108-12.

Efficacy of a live oral cholera vaccine in human volunteers.


A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.

[Indexed for MEDLINE]

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