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Curr Opin Immunol. 1994 Oct;6(5):791-6.

The induction of tolerance to alloantigens using HLA-based synthetic peptides.

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Department of Pediatrics, Stanford University School of Medicine, California 94305.


The identification of immunomodulatory approaches that allow the induction of antigen-specific unresponsiveness is required for long-term graft survival without the complications of chronic immunosuppression. Recent novel strategies based upon treatment with synthetic peptides corresponding to linear sequences of MHC class I and II molecules reproducibly induce tolerance to alloantigens. Although the mechanisms involved are still not completely understood, the phenomenology reported makes these approaches promising for evaluation in clinical trials.

[Indexed for MEDLINE]

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