MHC class II restricted tumor antigens and the role of CD4+ T cells in cancer immunotherapy

Curr Opin Immunol. 1994 Oct;6(5):741-5. doi: 10.1016/0952-7915(94)90078-7.

Abstract

Recent studies in human and murine systems suggest a central role for CD4+ T cells in initiating, effecting and maintaining anti-tumor immunity. Characterization of the tumor-associated antigens recognized by CD4+ T cells may prove critical to the success of cancer immunotherapy strategies.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Antigens, Neoplasm / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • HLA-D Antigens / immunology
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Immune Tolerance / immunology
  • Immunologic Memory
  • Immunotherapy / methods*
  • Neoplasms / immunology
  • Neoplasms / therapy*

Substances

  • Antigens, Neoplasm
  • HLA-D Antigens
  • Histocompatibility Antigens Class II