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Curr Opin Immunol. 1994 Oct;6(5):741-5.

MHC class II restricted tumor antigens and the role of CD4+ T cells in cancer immunotherapy.

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Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.


Recent studies in human and murine systems suggest a central role for CD4+ T cells in initiating, effecting and maintaining anti-tumor immunity. Characterization of the tumor-associated antigens recognized by CD4+ T cells may prove critical to the success of cancer immunotherapy strategies.

[Indexed for MEDLINE]

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