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Am J Med. 1995 Jan 16;98(1A):95S-98S.

Androgenetic alopecia: an autosomal dominant disorder.

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  • 1Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195-5032.


A hereditary, androgen-driven disorder, androgenetic alopecia is the most common form of alopecia in humans: its prevalence is 23-87%. Central alopecia is more severe in men; women are more likely to experience diffuse thinning. The acute onset of alopecia in those with inflammatory diseases of the scalp suggests a variety of etiologies, including the impact of inflammatory cells, release of cytokines, presence of growth factors, and increased interaction of stromal cells. Therapeutic modalities, which are most effective when used in combinations, utilize hair growth promoters, antiandrogens, and androgen blockade agents.

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