Format

Send to

Choose Destination
Scand J Immunol. 1995 Jan;41(1):94-7.

Cathepsin B generates the most common form of amyloid A (76 residues) as a degradation product from serum amyloid A.

Author information

1
Department of Medicine, Indiana University School of Medicine, Indianapolis.

Abstract

Amyloid A protein (AA), the chief constituent of reactive amyloid deposits, is derived from serum amyloid A (SAA) and most commonly corresponds to the amino-terminal 76 residues (AA76). Digestion of recombinant human SAA1 with a lysosomal thiol protease, cathepsin B, and analysis of the products by SDS-PAGE and amino-terminal sequencing revealed that AA76 was generated as a minor and transient degradation product. Digestion with neutrophil elastase generated intermediates different from AA76. This finding suggests that cathepsin B may play an important role in amyloid fibrilogenesis by converting SAA to AA.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center