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J Biol Chem. 1995 Jan 13;270(2):503-6.

Lipid modifications of trimeric G proteins.

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Department of Pharmacology, University of California, San Francisco 94143.


G protein alpha subunits and beta gamma dimers are covalently modified by lipids. The emerging picture is one in which attached lipids provide more than just a nonspecific "glue" for sticking G proteins to membranes. We are only beginning to understand how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites. In addition, regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins.

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