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Breast Cancer Res Treat. 1994;32(1):39-47.

The p53 tumor suppressor gene in breast cancer.

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Department of Medicine/Medical Oncology, University of Texas Health Science Center, San Antonio 78284-7884.


Alterations of the p53 tumor suppressor gene are the most common genetic changes found so far in breast cancer, suggesting that the gene plays a central role in the development of the disease. p53 functions as a negative regulator of cell growth, and alterations in the gene lead to loss of this negative growth regulation and more rapid cell proliferation. A number of independent groups using different methods of detection have shown that p53 alterations are associated with more aggressive tumor biologic factors and a poorer prognosis in breast cancer patients. Because of its possible role in the regulation of apoptosis and response to DNA damage, p53 status could also be a predictive marker for response to hormonal or chemotherapy.

[Indexed for MEDLINE]

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