Format

Send to

Choose Destination
Biochim Biophys Acta. 1995 Jan 19;1246(2):109-27.

Contribution of mutant analysis to the understanding of enzyme catalysis: the case of class A beta-lactamases.

Author information

1
Laboratoire d'Enzymologie et Centre d'Ingénierie des Protéines, Université de Liège, Belgium.

Abstract

Class A beta-lactamases represent a family of well studied enzymes. They are responsible for many antibiotic resistance phenomena and thus for numerous failures in clinical chemotherapy. Despite the facts that five structures are known at high resolution and that detailed analyses of enzymes modified by site-directed mutagenesis have been performed, their exact catalytic mechanism remains controversial. This review attempts to summarize and to discuss the many available data.

PMID:
7819278
DOI:
10.1016/0167-4838(94)00177-i
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for ORBi (University of Liege)
Loading ...
Support Center