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Arthritis Rheum. 1995 Jan;38(1):110-4.

Mannose-binding protein gene polymorphism in systemic lupus erythematosus.

Author information

1
Epidemiology Research Unit, University of Manchester, UK.

Abstract

OBJECTIVE:

To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE).

METHODS:

MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls.

RESULTS:

The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3).

CONCLUSION:

Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.

PMID:
7818559
DOI:
10.1002/art.1780380117
[Indexed for MEDLINE]

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