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Arthritis Rheum. 1995 Jan;38(1):105-9.

Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation.

Author information

1
Body Composition Laboratory, USDA HNRCA, Tufts University, Boston, MA 02111.

Abstract

OBJECTIVE:

To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects.

METHODS:

We measured levels of vitamin B6 in 23 adults with well-controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight.

RESULTS:

Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal-5'-phosphate (PLP) were lower in the RA patient group (mean +/- SD 46.1 +/- 48.1 versus 69.3 +/- 58.4 nmoles/liter; P < 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor alpha (TNF alpha) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs.

CONCLUSION:

PLP levels are reduced in patients with RA. This reduction is associated with TNF alpha production by PBMC.

PMID:
7818558
[Indexed for MEDLINE]

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