Send to

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 1994 Aug 29;178(1):99-102.

Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens.

Author information

  • 1Department of Psychiatry, Yale University School of Medicine, VA Medical Center, West Haven, CT 06516.


The effect of systemic ethanol administration on the extracellular levels of glutamate in the hippocampus and nucleus accumbens of conscious rats was assessed using microdialysis. At 0.5 g/kg, ethanol caused a sustained increase in the levels of glutamate in both regions. Following 1.0 g/kg, response was observed in the nucleus accumbens while a trend towards a decrease in glutamate levels occurred in hippocampus. Injection of 2.0 g/kg ethanol decreased these levels in both regions. These findings suggest a relationship between the previously reported biphasic behavioral consequence of ethanol and its effect on glutamatergic neurotransmission.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk