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Nature. 1995 Jan 12;373(6510):123-6.

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.

Author information

1
Aaron Diamond AIDS Research Center, NYU School of Medicine, New York 10016.

Abstract

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

PMID:
7816094
DOI:
10.1038/373123a0
[Indexed for MEDLINE]
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