Format

Send to

Choose Destination
Intervirology. 1994;37(2):58-67.

Epidemiological studies on hepatitis C virus infection: detection, prevalence, exposure and prevention.

Author information

1
Viral Hepatitis Research Foundation of Japan, Tokyo.

Abstract

Highly sensitive and specific tests for HCV infection are now available for epidemiological studies. These include: (1) the second-generation ELISA or agglutination technique with supplemental testing; (2) serotyping of antibody; (3) detection of HCV-RNA by RT-nested double PCR with the 5' noncoding region for the highest sensitivity; (4) quantitation of HCV-RNA; (5) genotyping using specific primers in the core region, and (6) sequence analysis of E2/NS1 hypervariable region 1 to identify homology among HCV isolates. Transmission of HCV is commonly done by percutaneous routes, although the route in a significant proportion of sporadic infections is unknown. Sexual transmission and perinatal transmission appear to be relatively infrequent.

PMID:
7814243
DOI:
10.1159/000150359
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center