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Brain Res. 1994 Aug 29;655(1-2):246-50.

CNTF potentiates peripheral nerve regeneration.

Author information

1
Department of Neurology, Division of Neuromuscular Disease, The Ohio State University, College of Medicine, Columbus 43210.

Abstract

The effect of ciliary neurotrophic factor (CNTF) on peripheral nerve regeneration was studied in 6-week-old rats following sciatic nerve transection and juxtaposition of proximal and distal stumps. Rats received intraperitoneal recombinant human CNTF, 1 mg/kg every other day for 12 days. In all CNTF-treated animals, the distribution of the anterograde transport of [3H]leucine-labeled material within the distal stump showed a distinct peak activity 21-24 mm distal to the nerve transection site. In contrast, the radioactivity in control nerves declined rapidly, distributed as proximodistal gradient without a distinct peak. In addition, the amount of radioactivity returning from the growing axon tips in CNTF was significantly greater than controls. The correlative morphologic studies showed a well-advanced stage of myelination in regenerating axons in CNTF compared to controls. These combined in vivo correlative kinetic and morphological studies indicate that CNTF dramatically potentiates axonal regeneration by promoting a greater number of elongating axon tips into the distal stump.

PMID:
7812780
DOI:
10.1016/0006-8993(94)91621-7
[Indexed for MEDLINE]

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