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Biochem Biophys Res Commun. 1994 Dec 30;205(3):1681-7.

Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells.

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Department of Neurological Surgery, University of Southern California School of Medicine, Los Angeles 90033.


The competitive HMG-CoA reductase inhibitor lovastatin has been shown to suppress growth and induce morphological changes in a variety of non-glioma tumor cell lines. This study assesses the effects of this agent on the growth and survival of the human malignant glioma cell lines A172 and U87-MG. The response to the drug was investigated using a cell proliferation assay which revealed significant dose-dependent growth inhibition. Treatment with as little as 100 nM lovastatin over a period of 72 hours led to DNA degradation into nucleosome-sized fragments characteristic of apoptosis. Our data suggest that HMG-CoA reductase inhibitors such as lovastatin merit further investigation as potential therapeutic agents for the treatment of malignant gliomas.

[Indexed for MEDLINE]

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