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Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Jul-Oct;44(4-5):831-6.

[The characteristics of the anticonflict action of fenazepam in rats selected by the method of forced swimming].

[Article in Russian]


A method of classification of outbred albino rats by means of forced swimming in a tank filled with water and equipped by freely turning wheels was developed. Using this technique a population of albino rats can be divided into three groups: highly active (HA), low active (LA) animals, and rats with intermediate activity. HA animals exhibit stable behaviour in forced swimming and conflict situation paradigms. They are also more sensitive to a benzodiazepine anxiolytic phenazepam in conflict situation test. At the same time, LA rats decrease their activity and are less sensitive to phenazepam. Both groups (LA and HA) are not homogeneous: each of them includes animals demonstrating quite another type of behaviour compared with a majority of rats.

[Indexed for MEDLINE]

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