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Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Jul-Oct;44(4-5):731-7.

[The food-acquisition behavior of rats under conditions of the chronic activation and blockade of the neostriatal dopaminergic system].

[Article in Russian]

Abstract

Effects of three-week daily intrastriatal amphetamine (15 and 45 mcg) and haloperidol (5 mcg) microinjections were studied in rats in a Skinners's box. Enhancement of motor activity, stereotype movements, increase of rate of lever pressings were recorded at the background of amphetamine microinjections in a dose of 45 mcg. In animals with initially low level of conditioning dopaminergic striatal stimulation qualitatively changed behavioural strategy, which promoted the stable long-term activation of instrumental conditioning. Amphetamine in a dose of 15 mcg was ineffective. Haloperidol had the opposite effects, i. e., it impaired conditioned alimentary behaviour and induced parkinsonian-like akinetic status. The findings suggest an involvement of dopaminergic neostriatal system in conditioned food-procuring behavioural strategy.

PMID:
7810215
[Indexed for MEDLINE]

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