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Trends Genet. 1994 Nov;10(11):408-12.

RAP1: a protean regulator in yeast.

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Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.


The yeast protein RAP1 is a sequence-specific DNA-binding protein that binds to many promoters, to two elements that silence mating-type genes, and to [(C)1-3A]n tracts at telomeres. RAP1 is essential for cell viability and can function as either an activator or a repressor of transcription, depending upon the context of its binding site. Recent experiments suggest that its function may be determined by different sets of protein-protein interactions at promoters and silencers. At the ends of chromosomes, RAP1 plays an important role in both silencing (telomere position effect) and telomere structure.

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