Format

Send to

Choose Destination
FEBS Lett. 1995 Jan 3;357(2):207-11.

cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.

Author information

1
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

Abstract

PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-alpha-trypsin inhibitor (ITI) superfamily.

PMID:
7805892
DOI:
10.1016/0014-5793(94)01364-7
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center