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FEBS Lett. 1994 Dec 19;356(2-3):244-8.

ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1.

Author information

1
Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd., Shizuoka, Japan.

Abstract

Human BST-1, a bone marrow stromal cell surface molecule, is a GPI-anchored protein that facilitates the growth of pre-B cells. The deduced amino acid sequences of human and mouse BST-1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST-1 might possess ADP ribosyl cyclase activity. Here, we report the establishment of a stable transformant CHO cell line, which secretes truncated human soluble BST-1, and show that purified soluble BST-1 displays both ADP ribosyl cyclase and cADPR hydrolase activities.

PMID:
7805847
DOI:
10.1016/0014-5793(94)01279-2
[Indexed for MEDLINE]
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