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Curr Opin Oncol. 1994 Jul;6(4):367-71.

Cytogenetics and experimental models of sarcomas.

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1
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

Abstract

Many sarcomas contain characteristic chromosome translocations that result in the fusion of genes from two different chromosomes. This review focuses on the translocated genes that have been identified recently in Ewing's sarcoma, peripheral primitive neuroectodermal tumor, clear cell sarcoma, alveolar rhabdomyosarcoma, and myxoid liposarcoma. Each of these fusion genes encodes a DNA transcription factor that presumably regulates the function of other genes. Thus, a common mechanism of oncogenesis has been defined in histologically disparate varieties of sarcoma.

PMID:
7803537
[Indexed for MEDLINE]
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