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Nature. 1995 Jan 5;373(6509):37-43.

Acetylcholine receptor channel imaged in the open state.

Author information

1
MRC Laboratory of Molecular Biology, Cambridge, UK.

Abstract

The structure of the open-channel form of the acetylcholine receptor has been determined from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5 ms) mixing with droplets containing acetylcholine. Comparison with the closed-channel form shows that acetylcholine initiates small rotations of the subunits in the extracellular domain, which trigger a change in configuration of alpha-helices lining the membrane-spanning pore. The open pore tapers towards the intracellular membrane face, where it is shaped by a 'barrel' of alpha-helices having a pronounced right-handed twist.

PMID:
7800037
DOI:
10.1038/373037a0
[Indexed for MEDLINE]

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