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Gastroenterology. 1995 Jul;109(1):115-21.

Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice.

Author information

1
Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Abstract

BACKGROUND & AIMS:

Eradication of Helicobacter pylori infections in humans results in the healing of gastritis and gastric ulcers. This study used a mouse model to test whether oral vaccination can cure Helicobacter infection and gastritis.

METHODS:

Mice were infected with Helicobacter felis. Three weeks after infection, the mice were orally immunized with H. pylori urease B subunit. Control mice were simultaneously infected but sham immunized.

RESULTS:

Three to 8 weeks after oral immunization of H. felis-infected mice with recombinant H. pylori urease B subunit, the infection cleared and there was no evidence of gastritis. Vaccinated mice remained protected against two consecutive H. felis challenges.

CONCLUSIONS:

These results show that the lack of natural immunity against Helicobacter can be overcome by oral immunization and that vaccination offers a novel therapeutic approach to Helicobacter-induced gastritis.

PMID:
7797009
[Indexed for MEDLINE]

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