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Immunity. 1995 Jun;2(6):573-85.

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0534, USA.

Abstract

Mice transgenic for SV40 T antigen (Tag) under control of the rat insulin promoter (RIP) develop two alternative immunological phenotypes: tolerance or autoimmunity towards Tag. We utilized the T cell receptor (TCR) genes expressed in a Tag-specific CD4+ cell from an autoimmune RIP-Tag mouse to generate two lines of TCR transgenic mice in which either 10% or 90% of peripheral T cells express the transgenic TCR. When cross-bred to the tolerant RIP1-Tag2 line, mice from the low frequency TCR line showed partial deletion of peripheral Tag-specific T cells and nonresponsiveness of those that remained. In contrast, crossbred mice in which transgenic T cells comprised a majority of the T cell population were nontolerant both in vivo and in vitro. Thus, tolerization of CD4+ T cells specific for a rare self-antigen may fail if too many autoreactive T cells develop.

PMID:
7796292
DOI:
10.1016/1074-7613(95)90002-0
[Indexed for MEDLINE]
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