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Annu Rev Med. 1976;27:245-61.

Vitamin K and the oral anticoagulant drugs.


The evolution of vitamin K, from a dietary deficiency in birds to a postribosomal modifier of prothrombin in man, has been a fascinating scientific saga. Its antivitamin, the oral anticoagulant drugs, has been a powerful probe both of vitamin K action and of drug interactions. These agents have emerged from a limbo of clinical therapeutics to become a light of human pharmacology.

[Indexed for MEDLINE]

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