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Am J Psychiatry. 1995 Jul;152(7):1084-6.

Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.

Author information

1
Soroka Medical Center, Kupat Holim Sick Fund of the Histadrut, Beersheba, Israel.

Abstract

OBJECTIVE:

Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder.

METHOD:

Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol.

RESULTS:

The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal.

CONCLUSIONS:

The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.

PMID:
7793450
DOI:
10.1176/ajp.152.7.1084
[Indexed for MEDLINE]

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