Transition state and multisubstrate analog inhibitors

Methods Enzymol. 1995:249:284-312. doi: 10.1016/0076-6879(95)49039-6.

Authors

A Radzicka¹, R Wolfenden

Affiliation

¹ Department of Biochemistry, University of North Carolina, Chapel Hill 27514, USA.

PMID: 7791615
DOI: 10.1016/0076-6879(95)49039-6

No abstract available

MeSH terms

Adenosine Deaminase / chemistry
Adenosine Deaminase / drug effects
Adenosine Deaminase / metabolism
Anions
Cations
Cytidine Deaminase / chemistry
Cytidine Deaminase / drug effects
Cytidine Deaminase / metabolism
Drug Design
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / classification
Enzyme Inhibitors / metabolism
Enzyme Inhibitors / pharmacology*
Enzymes / chemistry
Enzymes / drug effects*
Enzymes / metabolism
Kinetics
Models, Chemical
Water / chemistry
Water / metabolism

Substances

Anions
Cations
Enzyme Inhibitors
Enzymes
Water
Adenosine Deaminase
Cytidine Deaminase