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The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.
Endocrinology. 1995 Jul;136(7):3146-53. doi: 10.1210/endo.136.7.7789342.
Endocrinology. 1995.
PMID: 7789342
Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.
Neumann S, Krohn K, Chey S, Paschke R.
Neumann S, et al.
Horm Metab Res. 2001 May;33(5):263-9. doi: 10.1055/s-2001-15119.
Horm Metab Res. 2001.
PMID: 11440271
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