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Br J Psychiatry. 1995 Mar;166(3):382-5.

Recurrent affective syndromes in bipolar and unipolar mood disorders at follow-up.

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1
Payne Whitney Clinic, New York Hospital-Cornell University Medical Center, NY 10021, USA.

Abstract

BACKGROUND:

It is in dispute whether affective relapse disrupts psychosocial functioning to the same extent in depressed and manic patients.

METHOD:

A prospective, naturalistic, longitudinal follow-up of 84 unipolar and bipolar affectively disordered in-patients was conducted to examine the extent of recurrent affective syndromes and their relationship to overall outcome. Global adjustment relative to relapse was assessed at 2- and 4.5-year follow-ups.

RESULTS:

Nearly half of the bipolar patients had subsequent syndromes, which were often associated with uniformly poor psychosocial functioning. Fewer than one-quarter of those with recurrences had steady work performance. Bipolar patients taking lithium alone had fewer recurrences than those taking lithium as well as neuroleptics (P < 0.05). Bipolar and unipolar patients relapsed with equal frequency, but unipolar relapse was less often associated with readmission to hospital, work impairment, or uniformly poor functioning.

CONCLUSION:

Affective relapse in bipolar disorders was more detrimental to overall functioning than was recurrence in unipolar depression.

PMID:
7788132
[Indexed for MEDLINE]
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