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Acta Neurol Scand. 1995 Feb;91(2):149-52.

Absence of 4,977-bp deletion of blood cell mitochondrial DNA in patients with young-onset Parkinson's disease.

Author information

1
Neurological Institute, Veterans General Hospital, Taipei, Taiwan, ROC.

Abstract

Decreased mitochondrial Complex I activities and a 4,977-bp deletion in mitochondrial DNA (mtDNA) have been reported in patients with Parkinson's disease. Based on the assumption of possible links between this 4,977-bp deletion and the etiology of Parkinson's disease, we analyzed mtDNA of blood cells from 15 patients with young-onset Parkinson's disease after the DNA was amplified by polymerase chain reaction. We could not detect the 4,977-bp mtDNA deletion in any of these patients. This result suggests that Parkinson's disease is not a mitochondrial disease due to the 4,977-bp mtDNA deletion. The 4,977-bp deletion in mtDNA appears to be an age-related phenomenon.

PMID:
7785427
[Indexed for MEDLINE]

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