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Trends Genet. 1995 May;11(5):173-8.

Transcriptional regulation during the mammalian cell cycle.

Author information

1
Institut für Molekularbiologie und Tumorforschung (IMT), Philipps-Universität Marburg, Germany.

Abstract

Progression of the cell cycle in mammalian cells, as in all other organisms, is associated with the phase-specific transcription of defined sets of genes. Such periodically expressed genes frequently encode proteins that either directly control cell-cycle progression or function in metabolic processes linked to the cell cycle, such as nucleotide and DNA biosynthesis. Here, I summarize our current knowledge and views of the mechanisms governing the coupling of cell-cycle control mechanisms to transcriptional regulation, with particular emphasis on the transcription factor E2F and its connections with cyclin-dependent kinases and the retinoblastoma gene family.

PMID:
7785076
DOI:
10.1016/S0168-9525(00)89039-3
[Indexed for MEDLINE]

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