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Genomics. 1995 Mar 1;26(1):130-3.

Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25.

Author information

1
INSERM U242, Marseille, France.

Abstract

A human clone corresponding to the homologue of the murine Polycomb-like gene M33 has been used to map this gene (CBX2) to human chromosomes. Both somatic cell hybrid panels and FISH on metaphase chromosomes have been used. These techniques gave a consistent localization, at the tip of the long arm of chromosome 17 (17q25). This localization, as well as the potential role of a mammalian Polycomb-like protein, suggests a potential involvement in two different pathologies: the campomelic syndrome, an inherited disorder, and neoplastic disorders linked to allele loss already described in this region.

PMID:
7782071
DOI:
10.1016/0888-7543(95)80091-y
[Indexed for MEDLINE]

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