Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1995 May 29;365(2-3):115-9.

Almost the entire 5' non-translated region of hepatitis C virus is required for cap-independent translation.

Author information

1
Department of Virology, Faculty of Medicine, Leiden University, The Netherlands.

Abstract

To investigate which hairpin structures within the 5' untranslated region of hepatitis C virus (HCV) are necessary for cap-independent translation, mutants were constructed that lack one or more hairpin structures. Here we demonstrate, by constructing precisely defined hairpin deletion mutants, that with the exception of the most 5' located hairpin structure, which on deletion shows an increase on translation, each of the predicted hairpins is found to be essential for cap-independent translation. In addition, we demonstrate that HCV 5'UTR driven translation is stimulated by poliovirus 2Apro co-expression.

PMID:
7781762
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center